| |
| |
Current Selection Filters |
|
|
|
|
|
| |
|
| Risk 5: Occurrence of Serious Cardiac Dysrhythmias |
|
|
|
|
|
| |
| Crosscutting Area : Human Health and Countermeasures |
| |
 Discipline : Cardiovascular Alterations |
| |
| Description : Serious cardiac dysrhythmias may occur due to prolonged exposure to hypogravity or asymptomatic cardiac disease. |
| |
|
Context / Risk Factors :
Other physiological changes, such as altered neural and hormonal regulation, diminished cardiac mass and cardiac remodeling, and fluid and electrolyte alterations, may affect occurence of dysrhythmias. Flight duration, gender, and pre-existing cardiovascular disease are also risk factors.
|
| |
| Justification / Rationale : Cardiac rhythm disturbances have been observed on several occasions during space flight but the occurrence of space flight induced arrhythmias has not been documented. Recent flight and ground-based data demonstrate alterations in cardiac electrical activity, which may indicate altered cardiac electrical stability. If space flight increases the risk of serious cardiac dysrhythmias this could lead to syncope and/or death posing risk both to crewmembers and to the mission. |
| |
| Reference Missions :
|
| |
| |
 |
| |
Risk Rating
|
|
|
| |
Current Countermeasures
|
- Resuscitation equipment, including onboard defibrillator
- Crew medical screening
- Onboard monitoring
|
|
|
| |
Projected Countermeasures or Mitigations and Other Deliverables with their CRL/TRL scores
|
- Electrical cardioversion (Equipment currently on board, efficacy not demonstrated in space environment) [CRL 1]
- Nutritional countermeasure [CRL 2]
- Pharmaceutical countermeasure [CRL 1]
- Pre-flight and in-flight testing and monitoring to assess altered susceptibility to dysrhythmias [CRL 7]
|
|
|
| |
Research & Technology Questions
|
|
|
| |
Related Risks
|
|
|
| |
Important References
|
|
Fritsch-Yelle JM, Leuenberger UA, D'Aunno DS, Rossum AC, Brown TE, Wood ML, Josephson ME, Goldberger AL. An Episode of Ventricular Tachycardia During Long-Duration Spaceflight. The American Journal of Cardiology. 1998 June;81: 1391-1392.
|
|
Smith RF, Stanton K, Stoop D, Brown D, Januez W, King P. Vectorcardiographic Changes During Extended Space flight (M093): Observations at Rest and During Exercise. In: Biomedical Results of Skylab (NASA SP-377). Johnston RS and Dietlein LF, editors. Washington, DC: NASA 339-350, 1977.
|
|
Rossum AC, Wood ML, Bishop Sl, Deblcok H, Charles JB. Evaluation of Cardiac Rhythym Disturbances During Extravehicular Activity. The American Journal of Cardiology. 1997 April;79: 1153-1155.
|
|
Charles JB, Bungo MW, Fortner GW. Cardiopulmonary Function. In: Nicogossian A, Huntoon C, Pool S, and (editors). Space Physiology and Medicine. 3rd ed. Philadelphia, PA: Lea & Febiger, 286-304, 1994.
|
|
|
|
|
 |
|
 |
|
