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27 R & T Questions found.
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For Demonstration Purpose Only. Task data is mocked up.
 
1k: Are hypogravity-induced changes in bone density, geometry, and architecture reversible upon encountering partial gravity exposure, or on return to full gravity (1-G)?
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1 Tasks found.
1 A Model of Circadian Disruption in the Space Environment
 
A Quantitative Test of On-Orbit Exercise Countermeasures for Bone Demineralization Using a Bedrest Analog
Principal Investigator :  Cavanagh, Peter
 
Abstract :This is short description about the task. Could include objectives and significance of task as well. We don't expect very detailed explaination here. For more information about the task a link will be provided below.
 
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Organization :  BRC
 
Proposal By :  BRC
 
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(Links to research & technology questions were created for demonstration purposes. They have not been validated and should not be used for anything other than demonstration purposes)

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No. Question
1a What is the relative risk of sustaining a traumatic and/or stress fracture for a given decrement in bone mineral density, or alteration in bone geometry, in an astronaut-equivalent population who are physically active?
1b Will a period of rapid bone loss in hypogravity be followed by a slower rate of loss approaching a basal bone mineral density (BMD)? What are the estimated site-specific fracture risks as one approaches basal BMD?
1c Is there an additive or synergistic effect of gonadal hormone deficiency in men or women on bone loss during prolonged exposure to hypogravity?
1d What biophysical modalities, nutritional modifications, and pharmacological agents (alone or in combination) will most effectively minimize the decrease in bone mass due to extended hypogravity exposure?
2c Which cellular and biochemical changes in bone cell biology alter fracture healing under microgravity conditions?
2d Does the presence of microgravity-induced alteration in bone remodeling and/or osteoporosis affect fracture callus remodeling?
2e How do changes in skeletal muscle-bone interactions during space flight contribute to altered fracture healing in microgravity?
2f Do biophysical modalities play a role in improving fracture healing in a microgravity environment?
2g Do biophysical modalities play a role in improving fracture healing in the presence of bone loss in a microgravity environment?
2h Are there anabolic agents, growth factors, or cytokines that will speed fracture repair during microgravity in combination with active bone loss due to unloading?
2i What technologies will be used to diagnose fractures of the axial and appendicular skeleton in a space environment?
 
 
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