Tasks
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| For Demonstration Purpose Only. Task data is mocked up. |
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| 2b: Are there site-specific differences or differences in healing diaphyseal bone versus metaphyseal bone under microgravity or partial-gravity conditions? |
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| A Model of Circadian Disruption in the Space Environment |
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| Principal Investigator : Menaker, Michael |
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| Abstract :This is short description about the task. Could include objectives and significance of task as well. We don't expect very detailed explaination here. For more information about the task a link will be provided below. |
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| To get more information about the task click Here |
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| Organization : NSBRI |
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| Proposal By : NSBRI |
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Related Research & Technology Questions:(Links to research & technology questions were created for demonstration purposes. They have not been validated and should not be used for anything other than demonstration purposes)
| 1a |
What is the relative risk of sustaining a traumatic and/or stress fracture for a given decrement in bone mineral density, or alteration in bone geometry, in an astronaut-equivalent population who are physically active? |
| 1b |
Will a period of rapid bone loss in hypogravity be followed by a slower rate of loss approaching a basal bone mineral density (BMD)? What are the estimated site-specific fracture risks as one approaches basal BMD? |
| 1c |
Is there an additive or synergistic effect of gonadal hormone deficiency in men or women on bone loss during prolonged exposure to hypogravity? |
| 1d |
What biophysical modalities, nutritional modifications, and pharmacological agents (alone or in combination) will most effectively minimize the decrease in bone mass due to extended hypogravity exposure? |
| 1h |
Does the hypogravity environment change the nutritional requirements for optimal bone health? |
| 1i |
What diagnostic tools can be utilized during multi-year missions to monitor and quantify changes in bone mass and bone strength? |
| 1j |
What systemic adaptations to hypogravity are important contributory factors to bone loss, evaluations of which are essential for effective countermeasure development (e.g., fluid shifts, altered blood flow, immune system adaptations)? |
| 1k |
Are hypogravity-induced changes in bone density, geometry, and architecture reversible upon encountering partial gravity exposure, or on return to full gravity (1-G)? |
| 1l |
What regimen (exercise, pharmacological, nutritional, or biomechanical including impact loading or artificial gravity exposure) will most effectively hasten restoration of bone mass and/or bone strength (geometry and architecture) to pre-flight values in returning crewmembers? |
| 2a |
Is the rate of fracture healing and the integrity of the healed fracture altered under hypogravity or unloaded conditions? |
| 2b |
Are there site-specific differences or differences in healing diaphyseal bone versus metaphyseal bone under microgravity or partial-gravity conditions? |
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